Current Research Collaborations
Weill Cornell Medical College-Qatar
WCMCQ–PI: Dr. Lotfi Chouchane
Dr. Mariam A. Al-Muftah and Ms. Moza AL-Kowari
“Apoptosis resistance in prostate cancer cells and cancer stem cells: Implications of pro- and anti-apoptotic molecules in neuroendocrine differentiation
Prostate cancer (PC) is the most common cancer in men in Qatar according to recent statistics of the year 2011. This study which is done in coordination with Weill Cornell Medical College Qatar (WCMC-Q) aims to investigate the mechanisms of resistance to apoptosis of NE cells using microRNA (miRNA) expression profiling on NE-enriched PC models to ultimately contribute to the development of novel drugs that can specifically target NE cells in prostate carcinoma and halt the progression into the aggressive castration resistant prostate cancer (CRPC) phase.
Institut Gustave-Roussy & Hamad Medical Corporation
“Graft versus Leukemia potential of allogeneic NK cells in human hematopoietic transplantation
This project is an ongoing partnership initiative between QBRI, Hamad Medical Corporation and Institut Gustave-Roussy. The project aim is to understand the impairment of NK cells function in patients with myeloid hemopathies and to optimize conditions for adoptive transfer of allogeneic NK cells to improve the GvL effect after transplantation.
Dr. Salem Chouaib
is the lead PI from Gustave-Roussy working with a joint team from QBRI & HMC scientists to achieve the goals of the GvL project. The research is being conducted in HMC’s new interim Translational Research Institute (iTRI) facility.
In addition, QBRI & HMC are strengthening their working relationship and are actively engaged in developing joint projects in the areas of Breast Cancer and Diabetes. The scientific leaders within HMC include
- Cancer - breast cancer
- Prof. Alexander Knuth, Medical Director, National Center for Cancer Care & Research (NCCCR)
- Dr. Salha Bujassoum Al-Bader, Director of Breast Cancer Screening
- Prof. Ramzi Mohammad, Head Research Medicine
- Diabetes – type II diabetes (T2D)
- Abdul-Badi Abou-Samra, MD., Ph.D., Chairman Department of Medicine
Dr. Mohamed Chikri
“Genome Wide Association Study
The genetic contribution to T2D is a well-recognized element with established susceptibility loci identified primarily through large-scale genome-wide association studies (GWAS). Part of this project is carried out in collaboration with scientists from CNRS France. The principal aim of the study is to conduct a whole genome genotyping array in Arabic population by using the Illumina high-density array Human Core BeadChip with Qatari and Moroccan populations as an example. The intent is to explore the implication of fine mapping of type 2 diabetes GWAS-identified-loci in order to provide insight into the genetics and physiology of T2D in Arabic countries.